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Analogs of Eap protein are conserved and prevalent in clinical Staphylococcus aureus isolates.


ABSTRACT: Map and Eap are secreted Staphylococcus aureus proteins that interact with various extracellular matrix molecules. PCR analysis using map primers yielded positive reactions in 97.9% of S. aureus isolates but not in Staphylococcus epidermidis isolates. Cloning and sequencing of the conferring genes revealed a high degree of overall homology combined with size variability of the gene product due to various repeat numbers and early translation termination in a poly(A) region. Thus, Map and Eap may provide a potential novel tool for S. aureus identification and typing.

SUBMITTER: Hussain M 

PROVIDER: S-EPMC96261 | biostudies-literature | 2001 Nov

REPOSITORIES: biostudies-literature

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Analogs of Eap protein are conserved and prevalent in clinical Staphylococcus aureus isolates.

Hussain M M   Becker K K   von Eiff C C   Peters G G   Herrmann M M  

Clinical and diagnostic laboratory immunology 20011101 6


Map and Eap are secreted Staphylococcus aureus proteins that interact with various extracellular matrix molecules. PCR analysis using map primers yielded positive reactions in 97.9% of S. aureus isolates but not in Staphylococcus epidermidis isolates. Cloning and sequencing of the conferring genes revealed a high degree of overall homology combined with size variability of the gene product due to various repeat numbers and early translation termination in a poly(A) region. Thus, Map and Eap may  ...[more]

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