Dataset Information

Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.

ABSTRACT:

Background

Haemophilus influenzae serotype a (Hia) can cause invasive disease similar to serotype b; no Hia vaccine is available. We describe the epidemiology of invasive Hia disease in the United States overall and specifically in Alaska during 2008-2017.

Methods

Active population- and laboratory-based surveillance for invasive Hia disease was conducted through Active Bacterial Core surveillance sites and from Alaska statewide invasive bacterial disease surveillance. Sterile-site isolates were serotyped via slide agglutination or real-time polymerase chain reaction. Incidences in cases per 100 000 were calculated.

Results

From 2008 to 2017, an estimated average of 306 invasive Hia disease cases occurred annually in the United States (estimated annual incidence: 0.10); incidence increased by an average of 11.1% annually. Overall, 42.7% of cases were in children aged <5 years (incidence: 0.64), with highest incidence among children aged <1 year (1.60). Case fatality was 7.8% overall and was highest among adults aged ≥65 years (15.1%). Among children aged <5 years, the incidence was 17 times higher among American Indian and Alaska Native (AI/AN) children (8.29) than among children of all other races combined (0.49). In Alaska, incidences among all ages (0.68) and among children aged <1 year (24.73) were nearly 6 and 14 times higher, respectively, than corresponding US incidences. Case fatality in Alaska was 10.2%, and the vast majority (93.9%) of cases occurred among AI/AN.

Conclusions

Incidence of invasive Hia disease has increased since 2008, with the highest burden among AI/AN children. These data can inform prevention strategies, including Hia vaccine development.

SUBMITTER: Soeters HM

PROVIDER: S-EPMC9628811 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.

Soeters Heidi M HM Oliver Sara E SE Plumb Ian D ID Blain Amy E AE Zulz Tammy T Simons Brenna C BC Barnes Meghan M Farley Monica M MM Harrison Lee H LH Lynfield Ruth R Massay Stephanie S McLaughlin Joseph J Muse Alison G AG Petit Susan S Schaffner William W Thomas Ann A Torres Salina S Watt James J Pondo Tracy T Whaley Melissa J MJ Hu Fang F Wang Xin X Briere Elizabeth C EC Bruce Michael G MG

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20210701 2

<h4>Background</h4>Haemophilus influenzae serotype a (Hia) can cause invasive disease similar to serotype b; no Hia vaccine is available. We describe the epidemiology of invasive Hia disease in the United States overall and specifically in Alaska during 2008-2017.<h4>Methods</h4>Active population- and laboratory-based surveillance for invasive Hia disease was conducted through Active Bacterial Core surveillance sites and from Alaska statewide invasive bacterial disease surveillance. Sterile-site ...[more]

PMID: 32589699

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Dataset Information

Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.

Background

Methods

Results

Conclusions

Publications

Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.

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