Dataset Information

Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis.

ABSTRACT:

Purpose

Existing research hints that people living with and beyond cancer are at an increased risk of stroke. However, there is insufficient evidence to appropriately inform guidelines for specific stroke prevention or management for cancer patients. We conducted a systematic review and meta-analysis to describe and quantify stroke incidence in people living with and beyond cancer.

Methods

Medline, CINAHL, and EMBASE were searched for epidemiological studies comparing stroke incidence between cancer and non-cancer patients. Reviewers independently extracted data; random-effects meta-analyses and quality assessment were performed.

Results

Thirty-six studies were narratively synthesised. Meta-analysis was conducted using seven studies. Methodological quality was high for most studies. Study populations were heterogeneous, and the length of follow-up and risk factors varied. There was a variation in risk between different cancer types and according to stroke type: pancreatic (HR 2.85 (95% CI 2.43-3.36), ischaemic) (HR 2.28 (95% CI 1.43-3.63), haemorrhagic); lung (HR 2.33 (95% CI 1.63-3.35), ischaemic) (HR 2.14 (95% CI 1.45-3.15), haemorrhagic); and head and neck (HR 1.54 (95% CI 1.40-1.69), haemorrhagic) cancers were associated with significantly increased incidence of stroke. Risk is highest within the first 6 months of diagnosis. Narrative synthesis indicated that several studies also showed significantly increased incidence of stroke in individuals with colorectal cancer, breast cancer, ovarian cancer, nasopharyngeal cancer, leukaemia, and myeloma, and those who have received radiotherapy for head and neck cancers and platinum-based chemotherapy may also have higher stroke incidence.

Conclusions

Stroke incidence is significantly increased after diagnosis of certain cancers.

Implications for cancer survivors

Cardiovascular risk should be assessed during cancer survivorship care, with attention to modifying shared cancer/cardiovascular risk factors.

SUBMITTER: Turner M

PROVIDER: S-EPMC9630245 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis.

Turner Melanie M Murchie Peter P Derby Sarah S Ong Ariel Yuhan AY Walji Lauren L McLernon David D Macleod Mary-Joan MJ Adam Rosalind R

Journal of cancer survivorship : research and practice 20211105 6

<h4>Purpose</h4>Existing research hints that people living with and beyond cancer are at an increased risk of stroke. However, there is insufficient evidence to appropriately inform guidelines for specific stroke prevention or management for cancer patients. We conducted a systematic review and meta-analysis to describe and quantify stroke incidence in people living with and beyond cancer.<h4>Methods</h4>Medline, CINAHL, and EMBASE were searched for epidemiological studies comparing stroke incid ...[more]

PMID: 34739710

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Dataset Information

Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis.

Purpose

Methods

Results

Conclusions

Implications for cancer survivors

Publications

Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis.

Similar Datasets

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