Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancer.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC9637107 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancer.
Chen Xuanrong X Shao Yi Y Wei Wanqing W Zhu Shimiao S Li Yang Y Chen Yutong Y Li Hanling H Tian Hao H Sun Guijiang G Niu Yuanjie Y Shang Zhiqun Z
Cell death & disease 20221105 11
Androgen receptor (AR) plays an important role in the progression of prostate cancer and has been targeted by castration or AR-antagonists. The emergence of castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT) is inevitable. However, it is not entirely clear how ADT fails or how it causes resistance. Through analysis of RNA-seq data, we nominate ARHGEF2 as a pivotal androgen-repressed gene. We show that ARHGEF2 is directly suppressed by androgen/AR. AR occupies th ...[more]
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