Ontology highlight
ABSTRACT:
SUBMITTER: Khanppnavar B
PROVIDER: S-EPMC9640557 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Khanppnavar Basavraj B Maier Julian J Herborg Freja F Gradisch Ralph R Lazzarin Erika E Luethi Dino D Yang Jae-Won JW Qi Chao C Holy Marion M Jäntsch Kathrin K Kudlacek Oliver O Schicker Klaus K Werge Thomas T Gether Ulrik U Stockner Thomas T Korkhov Volodymyr M VM Sitte Harald H HH
Nature communications 20221107 1
Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and xenobiotics across the plasma membrane in various tissues throughout the human body. OCT3 plays a key role in low-affinity, high-capacity uptake of monoamines in most tissues including heart, brain and liver. Its deregulation plays a role in diseases. Despite its importance, the structural basis of OCT3 function and its inhibition has remained enigmatic. Here we describe the cryo-EM structure of human OC ...[more]