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RHO GTPase family in hepatocellular carcinoma.

ABSTRACT: RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and metastasis of cancer, playing an essential role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). This review first introduces the classification, structure, regulators and functions of RHO GTPases, then dissects its role in HCC, especially in migration and metastasis. Finally, we summarize inhibitors targeting RHO GTPases and highlight the issues that should be addressed to improve the potency of these inhibitors.

SUBMITTER: Wang T

PROVIDER: S-EPMC9644471 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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RHO GTPase family in hepatocellular carcinoma.

Wang Tiantian T Rao Dean D Yu Chengpeng C Sheng Jiaqi J Luo Yiming Y Xia Limin L Huang Wenjie W

Experimental hematology & oncology 20221108 1

RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and metastasis of cancer, playing an essential role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). This review first intr ...[more]

PMID: 36348464

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