Dataset Information

Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.

ABSTRACT:

Background

Development of cardiovascular disease in adults has been directly linked to an adverse metabolic phenotype. While there is evidence that development of these risk factors in childhood persists into adulthood and the development of cardiovascular disease, less is known about whether these risk factors are associated with target organ damage during adolescence.

Methods

We collected data from 379 adolescents (mean age 15.5, 60% male) with blood pressure between the 75th and 95th percentile to determine if there is a metabolic phenotype that predicts cardiovascular changes (left ventricular mass, systolic and diastolic function, pulse wave velocity, and renal function). We determined the number of risk factors for cardiovascular disease (hypertension, dyslipidemia, obesity, and insulin resistance) present in each participant. Generalized linear models were constructed to determine if the number of cardiovascular risk factors (CVRFs) were associated with measures of target organ damage.

Results

The number of CVRFs present were associated with statistically significant differences in increased left ventricular mass index, increased pulse wave velocity, decreased peak longitudinal strain, urine albumin to creatine ratio and echocardiographic parameters of diastolic dysfunction. Generalized linear models showed that dyslipidemia and insulin resistance were independently associated with markers of diastolic dysfunction (P ≤ .05) while increased blood pressure was associated with all makers of target organ damage (P ≤ .03).

Conclusions

These data suggest the of the number of CVRFs present is independently associated with early changes in markers of target organ damage during adolescence.

SUBMITTER: Price JJ

PROVIDER: S-EPMC9648121 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.

Price Joshua J JJ Urbina Elaine M EM Carlin Kristen K Becker Richard R Daniels Stephen R SR Falkner Bonita E BE Ferguson Michael M Hanevold Coral C Hooper Stephen R SR Ingelfinger Julie R JR Lande Marc B MB Martin Lisa J LJ Meyers Kevin K Mitsnefes Mark M Rosner Bernard B Samuels Joshua J Flynn Joseph T JT

Pediatrics 20220601 6

<h4>Background</h4>Development of cardiovascular disease in adults has been directly linked to an adverse metabolic phenotype. While there is evidence that development of these risk factors in childhood persists into adulthood and the development of cardiovascular disease, less is known about whether these risk factors are associated with target organ damage during adolescence.<h4>Methods</h4>We collected data from 379 adolescents (mean age 15.5, 60% male) with blood pressure between the 75th an ...[more]

PMID: 35502610

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Dataset Information

Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.

Background

Methods

Results

Conclusions

Publications

Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.

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