Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC9651905 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
Liu Lili L Khan Atlas A Sanchez-Rodriguez Elena E Zanoni Francesca F Li Yifu Y Steers Nicholas N Balderes Olivia O Zhang Junying J Krithivasan Priya P LeDesma Robert A RA Fischman Clara C Hebbring Scott J SJ Harley John B JB Moncrieffe Halima H Kottyan Leah C LC Namjou-Khales Bahram B Walunas Theresa L TL Knevel Rachel R Raychaudhuri Soumya S Karlson Elizabeth W EW Denny Joshua C JC Stanaway Ian B IB Crosslin David D Rauen Thomas T Floege Jürgen J Eitner Frank F Moldoveanu Zina Z Reily Colin C Knoppova Barbora B Hall Stacy S Sheff Justin T JT Julian Bruce A BA Wyatt Robert J RJ Suzuki Hitoshi H Xie Jingyuan J Chen Nan N Zhou Xujie X Zhang Hong H Hammarström Lennart L Viktorin Alexander A Magnusson Patrik K E PKE Shang Ning N Hripcsak George G Weng Chunhua C Rundek Tatjana T Elkind Mitchell S V MSV Oelsner Elizabeth C EC Barr R Graham RG Ionita-Laza Iuliana I Novak Jan J Gharavi Ali G AG Kiryluk Krzysztof K
Nature communications 20221111 1
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed a genome-wide association study of serum IgA levels in 41,263 individuals of diverse ancestries and identified 20 genome-wide significant loci, including 9 known and 11 novel loci. Co-localization analyses with expression QTLs prioritized candidate genes for 14 of 20 s ...[more]
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