Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants.
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ABSTRACT:
SUBMITTER: Svilenov HL
PROVIDER: S-EPMC9653429 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants.
Svilenov Hristo L HL Bester Romina R Sacherl Julia J Absmeier Ramona R Peters Carsten C Protzer Ulrike U Brockmeyer Carsten C Buchner Johannes J
Communications biology 20221112 1
Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the use of fusion proteins consisting of an antibody IgG Fc region and a human ACE2 domain to which the viral spike proteins bind. Here we create antiviral fusion proteins based on IgM scaffolds. The hexameric ACE2-IgM-Fc fusions can be efficiently produced in mammalian cells and they neutralize the infectious virus with picomolar affinity thus surpassing monomeric ACE2-I ...[more]
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