Ontology highlight
ABSTRACT:
SUBMITTER: Hosseini Nasab N
PROVIDER: S-EPMC9654533 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Hosseini Nasab Narges N Raza Hussain H Shim Rok Su RS Hassan Mubashir M Kloczkowski Andrzej A Kim Song Ja SJ
International journal of molecular sciences 20221031 21
To develop new alkaline phosphatase inhibitors (ALP), a series of pyrazolo-oxothiazolidine derivatives were synthesized and biologically assessed, and the results showed that all of the synthesized compounds significantly inhibited ALP. Specifically, compound <b>7g</b> displayed the strongest inhibitory activity (IC<sub>50</sub> = 0.045 ± 0.004 μM), which is 116-fold more active than monopotassium phosphate (IC<sub>50</sub> = 5.242 ± 0.472 μM) as a standard reference. The most potent compound am ...[more]