Ontology highlight
ABSTRACT:
SUBMITTER: Vourkou E
PROVIDER: S-EPMC9655709 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Vourkou Ergina E Paspaliaris Vassilis V Bourouliti Anna A Zerva Maria-Christina MC Prifti Engie E Papanikolopoulou Katerina K Skoulakis Efthimios M C EMC
International journal of molecular sciences 20221026 21
Accumulation of highly post-translationally modified tau proteins is a hallmark of neurodegenerative disorders known as tauopathies, the most common of which is Alzheimer's disease. Although six tau isoforms are found in the human brain, the majority of animal and cellular tauopathy models utilize a representative single isoform. However, the six human tau isoforms present overlapping but distinct distributions in the brain and are differentially involved in particular tauopathies. These observa ...[more]