Ontology highlight
ABSTRACT:
SUBMITTER: Anwar M
PROVIDER: S-EPMC9663300 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Anwar Mohiemen M Arendt Maja-Louise ML Ramachandran Mohanraj M Carlsson Anette A Essand Magnus M Akusjärvi Göran G Alusi Ghasan G Öberg Daniel D
Cancer gene therapy 20220520 11
There is a great demand for improved oncolytic viruses that selectively replicate within cancer cells while sparing normal cells. Here, we describe a novel oncolytic adenovirus, Ixovex-1, that obtains a cancer-selective replication phenotype by modulating the level of expression of the different, alternatively spliced E1B mRNA isoforms. Ixovex-1 is a recombinant adenovirus that carries a single point mutation in the E1B-93R 3' splice acceptor site that results in overexpression of the E1B-156R s ...[more]