Dataset Information

Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.

ABSTRACT:

Background

Sleep disturbance (SD) is common in patients with cancer and has been associated with worse clinical outcomes. This cross-sectional study explored the prevalence of SD in a primary brain tumor (PBT) population, identified associated demographic and clinical characteristics, and investigated co-occurrence of SD with other symptoms and mood disturbance.

Methods

Demographic, clinical characteristics, MD Anderson Symptom Inventory-Brain Tumor, and Patient Reported Outcome Measurement Information System Depression and Anxiety Short-Forms were collected from PBT patients at study entry. Descriptive statistics, Chi-square tests, and independent t-tests were used to report results.

Results

The sample included 424 patients (58% male, 81% Caucasian) with a mean age of 49 years (range 18-81) and 58% with high-grade gliomas. Moderate-severe SD was reported in 19% of patients and was associated with younger age, poor Karnofsky Performance Status, tumor progression on MRI, and active corticosteroid use. Those with moderate-severe SD had higher overall symptom burden and reported more moderate-severe symptoms. These individuals also reported higher severity in affective and mood disturbance domains, with 3 to 4 times higher prevalence of depressive and anxiety symptoms, respectively. The most frequently co-occurring symptoms with SD were, drowsiness, and distress, though other symptoms typically associated with tumor progression also frequently co-occurred.

Conclusions

PBT patients with moderate-severe SD are more symptomatic, have worse mood disturbance, and have several co-occurring symptoms. Targeting interventions for sleep could potentially alleviate other co-occurring symptoms, which may improve life quality for PBT patients. Future longitudinal work examining objective and detailed subjective sleep reports, as well as underlying genetic risk factors, will be important.

SUBMITTER: King AL

PROVIDER: S-EPMC9665069 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.

King Amanda L AL Shuboni-Mulligan Dorela D DD Vera Elizabeth E Crandon Sonja S Acquaye Alvina A AA Boris Lisa L Burton Eric E Choi Anna A Christ Alexa A Grajkowska Ewa E Jammula Varna V Leeper Heather E HE Lollo Nicole N Penas-Prado Marta M Reyes Jennifer J Theeler Brett B Wall Kathleen K Wu Jing J Gilbert Mark R MR Armstrong Terri S TS

Neuro-oncology practice 20220622 6

<h4>Background</h4>Sleep disturbance (SD) is common in patients with cancer and has been associated with worse clinical outcomes. This cross-sectional study explored the prevalence of SD in a primary brain tumor (PBT) population, identified associated demographic and clinical characteristics, and investigated co-occurrence of SD with other symptoms and mood disturbance.<h4>Methods</h4>Demographic, clinical characteristics, MD Anderson Symptom Inventory-Brain Tumor, and Patient Reported Outcome M ...[more]

PMID: 36388423

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Project description:PurposeTo investigate the frequency of sleep disturbance and its effects on quality of life in adults with untreated primary brain tumors.MethodsThis cross-sectional study recruited 68 and 35 patients with newly diagnosed benign and malignant brain tumors, respectively. All participants completed the Chinese versions of the Athens Insomnia Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, Brief Fatigue Inventory, and EORTC-QLQ-BN20 for quality-of-life assessment. An actigraph was used to measure sleep parameters [e.g., dichotomy index (I < O)], for at least 3 consecutive days in untreated status.ResultsThe majority of the patients with benign and malignant tumors had meningioma (57.4%) and glioblastoma (40%), respectively. The prevalence of insomnia, poor sleep quality, and excessive daytime sleepiness was 59.2%, 77.7%, and 4.9%, respectively. The prevalence rates of sleep disturbances were not affected by tumor locations (suprasellar vs. non-suprasellar tumors) and tumor types (benign vs. malignant tumors). Only 36 participants completed actigraphy assessments (I < O = 95.4) due to having a tight schedule, actigraph malfunction, or not having the habit of wearing a wristwatch; 61% of them experienced circadian rhythm disruption (I < O ≤ 97.5). Insomnia was the only sleep parameter that significantly affected quality of life after controlling for potential confounders (B = 0.54, p = 0.03, adjusted R2 = 0.60).ConclusionMore than 60% of the patients with primary malignant and benign brain tumors experienced insomnia, poor sleep quality, and circadian rhythm disruption. Insomnia was independently correlated with quality of life in untreated status. Health-care providers can apply these findings to design effective interventions targeting sleep disturbance to improve quality of life in this population.Supplementary informationThe online version contains supplementary material available at 10.1007/s41105-022-00436-y.

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Dataset Information

Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.

Background

Methods

Results

Conclusions

Publications

Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.

Similar Datasets

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