Dataset Information

Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.

ABSTRACT:

Background

Advanced magnetic resonance imaging (MRI) methods can provide more specific information about various microstructural tissue changes in multiple sclerosis (MS) brain. Quantitative measurement of T₁ and T₂ relaxation, and diffusion basis spectrum imaging (DBSI) yield metrics related to the pathology of neuroinflammation and neurodegeneration that occurs across the spectrum of MS.

Objective

To use relaxation and DBSI MRI metrics to describe measures of neuroinflammation, myelin and axons in different MS subtypes.

Methods

103 participants (20 clinically isolated syndrome (CIS), 33 relapsing-remitting MS (RRMS), 30 secondary progressive MS and 20 primary progressive MS) underwent quantitative T₁, T₂, DBSI and conventional 3T MRI. Whole brain, normal-appearing white matter, lesion and corpus callosum MRI metrics were compared across MS subtypes.

Results

A gradation of MRI metric values was seen from CIS to RRMS to progressive MS. RRMS demonstrated large oedema-related differences, while progressive MS had the most extensive abnormalities in myelin and axonal measures.

Conclusion

Relaxation and DBSI-derived MRI measures show differences between MS subtypes related to the severity and composition of underlying tissue damage. RRMS showed oedema, demyelination and axonal loss compared with CIS. Progressive MS had even more evidence of increased oedema, demyelination and axonal loss compared with CIS and RRMS.

SUBMITTER: Vavasour IM

PROVIDER: S-EPMC9665421 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.

Vavasour Irene M IM Sun Peng P Graf Carina C Yik Jackie T JT Kolind Shannon H SH Li David Kb DK Tam Roger R Sayao Ana-Luiza AL Schabas Alice A Devonshire Virginia V Carruthers Robert R Traboulsee Anthony A Moore Gr Wayne GW Song Sheng-Kwei SK Laule Cornelia C

Multiple sclerosis (Houndmills, Basingstoke, England) 20210616 3

<h4>Background</h4>Advanced magnetic resonance imaging (MRI) methods can provide more specific information about various microstructural tissue changes in multiple sclerosis (MS) brain. Quantitative measurement of T<sub>1</sub> and T<sub>2</sub> relaxation, and diffusion basis spectrum imaging (DBSI) yield metrics related to the pathology of neuroinflammation and neurodegeneration that occurs across the spectrum of MS.<h4>Objective</h4>To use relaxation and DBSI MRI metrics to describe measures ...[more]

PMID: 34132126

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Dataset Information

Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.

Background

Objective

Methods

Results

Conclusion

Publications

Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.

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