Ontology highlight
ABSTRACT:
SUBMITTER: Cadieux N
PROVIDER: S-EPMC96836 | biostudies-literature | 1999 Sep
REPOSITORIES: biostudies-literature
Cadieux N N Plante M M Rioux C R CR Hamel J J Brodeur B R BR Martin D D
Infection and immunity 19990901 9
The cross-bactericidal and cross-protective activities of a monoclonal antibody (MAb) named Me-7, which is directed against an antigenically highly conserved epitope on the meningococcal NspA protein, were studied. This MAb efficiently killed in vitro, in the presence of rabbit or human serum, 13 of 14 meningococcal strains tested, including 9 of 9, 2 of 3, and 2 of 2 strains of serotypes B, A, and C, respectively. MAb Me-7 also significantly reduced by more than 75% the levels of bacteremia rec ...[more]