Ontology highlight
ABSTRACT:
SUBMITTER: Diener C
PROVIDER: S-EPMC9691620 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Diener Christian C Dai Chengzhen L CL Wilmanski Tomasz T Baloni Priyanka P Smith Brett B Rappaport Noa N Hood Leroy L Magis Andrew T AT Gibbons Sean M SM
Nature metabolism 20221110 11
Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome in explaining this variation on a metabolite-by-metabolite level. Here, we perform analyses of variance for each of 930 blood metabolites robustly detected across a cohort of 1,569 individuals with paired genomic and microbiome data while controlling for a number of relevant covariates. We find that 595 (64%) of these blood metabolites ar ...[more]