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Targeting KRAS in Pancreatic Cancer.

ABSTRACT: Pancreatic cancer is mainly driven by mutations in the KRAS oncogene. While this cancer has shown remarkable therapy resistance, new approaches to inhibit mutated KRAS, KRAS activators and effectors show promise in breaking this therapeutic deadlock. Here, we review these innovations in therapies that target RAS signaling in pancreatic cancer from a clinical point of view. A number of promising approaches are currently in clinical trials or in clinical development. We focus on small-molecule drugs but also discuss immunotherapies and tumor vaccines.

SUBMITTER: Cowzer D

PROVIDER: S-EPMC9692903 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Targeting KRAS in Pancreatic Cancer.

Cowzer Darren D Zameer Mohammed M Conroy Michael M Kolch Walter W Duffy Austin G AG

Journal of personalized medicine 20221108 11

Pancreatic cancer is mainly driven by mutations in the KRAS oncogene. While this cancer has shown remarkable therapy resistance, new approaches to inhibit mutated KRAS, KRAS activators and effectors show promise in breaking this therapeutic deadlock. Here, we review these innovations in therapies that target RAS signaling in pancreatic cancer from a clinical point of view. A number of promising approaches are currently in clinical trials or in clinical development. We focus on small-molecule dru ...[more]

PMID: 36579598

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