Ontology highlight
ABSTRACT:
SUBMITTER: Marshall S
PROVIDER: S-EPMC9694948 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Marshall Skye S McGill Beth B Morcrette Helen H Winlove C Peter CP Chimerel Catalin C Petrov Peter G PG Bokori-Brown Monika M
Toxins 20221103 11
<i>Clostridium perfringens</i> epsilon toxin (Etx) is a pore forming toxin that causes enterotoxaemia in ruminants and may be a cause of multiple sclerosis in humans. To date, most in vitro studies of Etx have used the Madin-Darby canine kidney (MDCK) cell line. However, studies using Chinese hamster ovary (CHO) cells engineered to express the putative Etx receptor, myelin and lymphocyte protein (MAL), suggest that amino acids important for Etx activity differ between species. In this study, we ...[more]