Ontology highlight
ABSTRACT:
SUBMITTER: Nakanishi A
PROVIDER: S-EPMC9695645 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Nakanishi Anna A Okumura Hiroki H Hashita Tadahiro T Yamashita Aya A Nishimura Yuka Y Watanabe Chihiro C Kamimura Sakina S Hayashi Sanae S Murakami Shuko S Ito Kyoko K Iwao Takahiro T Ikeda Akari A Hirose Tomoyasu T Sunazuka Toshiaki T Tanaka Yasuhito Y Matsunaga Tamihide T
Viruses 20221108 11
Hepatitis B virus (HBV) specifically infects human hepatocytes and increases the risks of cirrhosis and liver cancer. Currently, nucleic acid analogs are the main therapeutics for chronic hepatitis caused by HBV infection. Although nucleic acid analogs can eliminate HBV DNA by inhibiting HBV reverse transcriptase, they cannot lead to negative conversion of covalently closed circular DNA (cccDNA) and hepatitis B surface antigen (HBsAg). In this study, we revealed that the antifilarial drug iverme ...[more]