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Glycogen Synthase Kinase 3β: A True Foe in Pancreatic Cancer.

ABSTRACT: Glycogen synthase kinase 3 beta (GSK-3β) is a serine/threonine protein kinase involved in multiple normal and pathological cell functions, including cell signalling and metabolism. GSK-3β is highly expressed in the onset and progression of multiple cancers with strong involvement in the regulation of proliferation, apoptosis, and chemoresistance. Multiple studies showed pro- and anti-cancer roles of GSK-3β creating confusion about the benefit of targeting GSK-3β for treating cancer. In this mini-review, we focus on the role of GSK-3β in pancreatic cancer. We demonstrate that the proposed anti-cancer roles of GSK-3β are not relevant to pancreatic cancer, and we argue why GSK-3β is, indeed, a very promising therapeutic target in pancreatic cancer.

SUBMITTER: Elmadbouh OHM

PROVIDER: S-EPMC9696080 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Glycogen Synthase Kinase 3β: A True Foe in Pancreatic Cancer.

Elmadbouh Omer H M OHM Pandol Stephen J SJ Edderkaoui Mouad M

International journal of molecular sciences 20221116 22

Glycogen synthase kinase 3 beta (GSK-3β) is a serine/threonine protein kinase involved in multiple normal and pathological cell functions, including cell signalling and metabolism. GSK-3β is highly expressed in the onset and progression of multiple cancers with strong involvement in the regulation of proliferation, apoptosis, and chemoresistance. Multiple studies showed pro- and anti-cancer roles of GSK-3β creating confusion about the benefit of targeting GSK-3β for treating cancer. In this mini ...[more]

PMID: 36430630

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