Ontology highlight
ABSTRACT:
SUBMITTER: Pham LV
PROVIDER: S-EPMC9698709 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Pham Long V LV Velázquez-Moctezuma Rodrigo R Fahnøe Ulrik U Collignon Laura L Bajpai Priyanka P Sølund Christina C Weis Nina N Holmbeck Kenn K Prentoe Jannick J Bukh Jens J
Viruses 20221115 11
Hepatitis C virus (HCV) genotype 4 is highly prevalent in the Middle East and parts of Africa. Subtype 4d has recently spread among high-risk groups in Europe. However, 4d infectious culture systems are not available, hampering studies of drugs, as well as neutralizing antibodies relevant for HCV vaccine development. We determined the consensus 4d sequence from a chronic hepatitis C patient by next-generation sequencing, generated a full-length clone thereof (pDH13), and demonstrated that pDH13 ...[more]