Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC9698989 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Yang Sixia S Pei Tingting T Wang Linshuang L Zeng Yi Y Li Wenxu W Yan Shihua S Xiao Wei W Cheng Weidong W
Molecules (Basel, Switzerland) 20221119 22
Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protective effects and mechanisms of SAL in SAMP8 mice. SAMP8 mice were administered with SAL and Ferrostatin-1 (Fer-1) for 12 weeks. Renal function, renal fibrosis, and ferroptosis in renal tissue were dete ...[more]