Dataset Information

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.

ABSTRACT:

Introduction

Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).

Aim

To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.

Material and methods

The study group consisted of 191 patients with AD and 168 controls.

Results

The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, p = 0.01).

Conclusions

The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.

SUBMITTER: Zaryczanska A

PROVIDER: S-EPMC9704459 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.

Zaryczañska Anna A Gleñ Jolanta J Zabłotna Monika M Nowicki Roman J RJ Trzeciak Magdalena M

Postepy dermatologii i alergologii 20220303 5

<h4>Introduction</h4>Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).<h4>Aim</h4>To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.<h4>Material and methods</h4>The study group consisted of 191 patients with AD and 168 controls.<h4>Results</h4>The TT genotype appeared to be most frequent in patients with seve ...[more]

PMID: 36457695

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Project description:BackgroundFLG encodes a large protein called profilaggrin, which plays a key role in maintaining an effective skin barrier against the environment. In this study, we identified FLG single nucleotide variations (FLG-SNVs) and evaluated the association of FLG-SNVs with clinical phenotypes including atopic dermatitis (AD)-associated minor clinical features, presence of specific allergic sensitization, and serum parameters.MethodsEighty-one Korean patients with AD were enrolled. AD-associated minor clinical features as well as allergic rhinitis and asthma were diagnosed by specialists. FLG-SNVs were identified by Sanger sequencing of entire exons through long-range PCR. Allergic sensitization to a specific allergen was evaluated by multiple allergen simultaneous test. Serologic parameters such as serum eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN) were measured.ResultsA total of seventy-three SNVs and 4 LOF mutations were successfully genotyped. rs71626704 and rs76413899 were significantly associated with a history of asthma and cheilitis (P = 0.002 and P = 0.033, respectively), however, the associations were not found statistically significant after adjustment by multiple comparisons. In addition, we detected haplotype blocks which were correlated with non-specific hand or foot dermatitis and scalp scale. We identified FLG-SNVs which were associated with sensitization to environmental allergens; rs62623409 and rs71625199 (P = 0.038 and P = 0.008, respectively). Patients with FLG P478S TT and history of allergic rhinitis showed a higher EDN level, and among those patients, the ones with asthma showed a higher ECP level.ConclusionThis study revealed the association of FLG-SNVs with AD-associated minor clinical features. We firstly identified rs71625199 which was associated with higher environmental allergic sensitization. We also suggest that FLG P478S is a kind of disease modifier which affects serologic parameters such as EDN and ECP.

Dataset Information

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.

Introduction

Aim

Material and methods

Results

Conclusions

Publications

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.

Similar Datasets

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