Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy.
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ABSTRACT:
SUBMITTER: Busch RM
PROVIDER: S-EPMC9709106 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy.
Busch Robyn M RM Yehia Lamis L Hu Bo B Goldman Melissa M Hermann Bruce P BP Najm Imad M IM McCarroll Steven A SA Eng Charis C
NPJ genomic medicine 20221129 1
Memory dysfunction is prevalent in temporal lobe epilepsy (TLE), but little is known about the underlying molecular etiologies. Single-nucleus RNA sequencing technology was used to examine differences in cellular heterogeneity among left (language-dominant) temporal neocortical tissues from patients with TLE with (n = 4) or without (n = 2) impairment in verbal episodic memory. We observed marked cell heterogeneity between memory phenotypes and identified numerous differentially expressed genes a ...[more]
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