Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial-mesenchymal transition interlinked with reprogrammed metabolism.
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ABSTRACT:
SUBMITTER: Leung D
PROVIDER: S-EPMC9719259 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial-mesenchymal transition interlinked with reprogrammed metabolism.
Leung Dilys D Price Zoe K ZK Lokman Noor A NA Wang Wanqi W Goonetilleke Lizamarie L Kadife Elif E Oehler Martin K MK Ricciardelli Carmela C Kannourakis George G Ahmed Nuzhat N
Journal of translational medicine 20221203 1
<h4>Background</h4>Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide. Chemotherapy resistance represents a significant clinical challenge and is the main reason for poor ovarian cancer prognosis. We identified novel expression of markers related to epithelial mesenchymal transitions (EMT) in a carboplatin resistant ovarian cancer cell line by proteomics. This was validated in the platinum resistant versus sensitive parental cell lines, as well as platinum resistant ver ...[more]
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