Dataset Information

No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.

ABSTRACT:

Background

Epidemiological data suggest that cancer patients have a reduced risk of subsequent Parkinson's disease (PD) development, but the prevalence of PD in melanoma patients is often reported to be increased. Causal relationships between cancers and PD have not been fully explored.

Objective

To study causal relationship between different cancers and PD.

Methods

We used GWAS summary statistics of 15 different types of cancers and two-sample Mendelian randomization to study the causal relationship with PD.

Results

There was no evidence to support a causal relationship between the studied cancers and PD. We also performed reverse analyses between PD and cancers with available full summary statistics (melanoma, breast, prostate, endometrial and keratinocyte cancers) and did not find evidence of causal relationship.

Conclusion

We found no evidence to support a causal relationship between cancers and PD and the previously reported associations could be a result of genetic pleiotropy, shared biology or biases.

SUBMITTER: Senkevich K

PROVIDER: S-EPMC9719261 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.

Senkevich Konstantin K Bandres-Ciga Sara S Yu Eric E Liyanage Upekha E UE Noyce Alastair J AJ Gan-Or Ziv Z

Journal of Parkinson's disease 20210101 2

<h4>Background</h4>Epidemiological data suggest that cancer patients have a reduced risk of subsequent Parkinson's disease (PD) development, but the prevalence of PD in melanoma patients is often reported to be increased. Causal relationships between cancers and PD have not been fully explored.<h4>Objective</h4>To study causal relationship between different cancers and PD.<h4>Methods</h4>We used GWAS summary statistics of 15 different types of cancers and two-sample Mendelian randomization to st ...[more]

PMID: 33646179

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Project description:Parkinson's disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients and society. B lymphocytes, a group of immune cells associated with humoral immunity, have been shown to be involved in the pathogenesis of PD. However, the causal relationship and potential pathogenic effects of B cell in PD remain unclear. Based on the three core hypotheses of the Mendelian randomization (MR) study, we explored causal associations between 190 B-cell immunological traits and 482,730 European individuals (Ncase = 33,674, Ncontrol = 449,056) from genome wide association studies by means of the two-sample bidirectional MR method. The inverse‑variance weighted method was selected as the main approach when conducting MR analysis. Finally, the results were verified by the heterogeneity and horizontal pleiotropy analyses. Five B-cell immunological phenotypes were nominally associated with PD at the significance threshold of P < 0.05. Concretely, IgD + CD38- B cell %lymphocyte (OR 1.052, 95% CI 1.001-1.106, P = 0.046), CD20 on IgD- CD24- B cell (OR 1.060, 95% CI 1.005-1.117, P = 0.032), CD38 on IgD+ CD24- B cell (OR 1.113, 95% CI 1.028-1.206, P = 0.009), and BAFF-R on CD20- B cell (OR 1.093, 95% CI 1.010-1.184, P = 0.027) were identified as risk factors for PD. Instead, CD38 on Plasma Blast-Plasma Cell (OR 0.894, 95% CI 0.802-0.996, P = 0.043) was proved to be protective. However, there is no statistically significant correlation between B cell and PD after Bonferroni correction. The results of reverse MR were negative, avoiding the reverse causal effects. Eventually, the association results were identified as stable across several sensitivity analyses. Briefly, our study might demonstrate the key factor of B cells in PD. Further studies are warranted to clarify the associations for early identification and immunotherapeutic development in PD patients.

Dataset Information

No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.

Background

Objective

Methods

Results

Conclusion

Publications

No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.

Similar Datasets

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