Construction of urease-negative mutants of Yersinia enterocolitica serotypes O:3 and o:8: role of urease in virulence and arthritogenicity.
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ABSTRACT:
SUBMITTER: Gripenberg-Lerche C
PROVIDER: S-EPMC97227 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
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Construction of urease-negative mutants of Yersinia enterocolitica serotypes O:3 and o:8: role of urease in virulence and arthritogenicity.
Gripenberg-Lerche C C Zhang L L Ahtonen P P Toivanen P P Skurnik M M
Infection and immunity 20000201 2
Yersinia enterocolitica serotype O:3 and O:8 urease-negative mutants unable to express the 19-kDa beta subunit of urease were constructed and tested for virulence and arthritogenicity. Our results indicate that urease is needed for full virulence in oral infections and that it is not an arthritogenic factor in the rat model. ...[more]
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