Ontology highlight
ABSTRACT:
SUBMITTER: van Neerven SM
PROVIDER: S-EPMC9727927 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
van Neerven Sanne M SM Smit Wouter L WL van Driel Milou S MS Kakkar Vaishali V de Groot Nina E NE Nijman Lisanne E LE Elbers Clara C CC Léveillé Nicolas N Heijmans Jarom J Vermeulen Louis L
EMBO molecular medicine 20221102 12
The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a global increase in mRNA translation. To compensate for the increased biosynthetic demand, cancer cells critically depend on protein chaperones to maintain proteostasis, although their function in CRC remains largely unexplored. In order to investigate the ro ...[more]