Ontology highlight
ABSTRACT:
SUBMITTER: Cho HJ
PROVIDER: S-EPMC9728164 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cho Hee Jun HJ Ryu Ki-Jun KJ Baek Kyoung Eun KE Lim Jeewon J Kim Taeyoung T Song Chae Yeong CY Yoo Jiyun J Lee Hee Gu HG
Journal of microbiology and biotechnology 20201001 10
Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays important roles in numerous cellular processes, including cell motility, adhesion, and proliferation, by regulating the activity of Rho GTPases. Its expression is altered in various human cancers and is associated with malignant progression. Here, we show that RhoGDI1 interacts with Cullin 3 (CUL3), a scaffold protein for E3 ubiquitin ligase complexes. Ectopic expression of CUL3 increases the ubiquitination of RhoGDI1. Furthermore, ...[more]