Ontology highlight
ABSTRACT:
SUBMITTER: Fasano C
PROVIDER: S-EPMC9737320 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Fasano Candida C Grossi Valentina V Forte Giovanna G Simone Cristiano C
Cells 20221123 23
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein-protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling effectors. PPIs in signaling and regulatory networks are known to be mediated by short linear motifs (SLiMs), which are conserved contiguous regions of 3-10 amino acids within interacting protein domai ...[more]