Lectin Drug Conjugates Targeting High Mannose N-Glycans.
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ABSTRACT:
SUBMITTER: Kurhade SE
PROVIDER: S-EPMC9738879 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Lectin Drug Conjugates Targeting High Mannose N-Glycans.
Kurhade Suresh E SE Ross Patrick P Gao Fei Philip FP Farrell Mark P MP
Chembiochem : a European journal of chemical biology 20220727 19
Cancer-associated alterations to glycosylation have been shown to aid cancer development and progression. An increased abundance of high mannose N-glycans has been observed in several cancers. Here, we describe the preparation of lectin drug conjugates (LDCs) that permit toxin delivery to cancer cells presenting high mannose N-glycans. Additionally, we demonstrate that cancer cells presenting low levels of high mannose N-glycans can be rendered sensitive to the LDCs by co-treatment with a type I ...[more]
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