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Emerging pharmacological treatment options for MAFLD.

ABSTRACT: Metabolic dysfunction-associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated with metabolic comorbidities, obesity, overweight, type 2 diabetes mellitus, and at least two metabolic risk factors, such as hypertension, hypertriglyceridemia, hypercholesterolemia, insulin resistance, and cardiovascular risk, increasing the risk of mortality. The excessive accumulation of fat comprises apoptosis, necrosis, inflammation and ballooning degeneration progressing to fibrosis, cirrhosis, and liver decompensations including hepatocellular carcinoma development. The limitation of approved drugs to prevent MAFLD progression is a paradigm. This review focuses on recent pathways and targets with evidence results in phase II/III clinical trials.

SUBMITTER: Rojas A

PROVIDER: S-EPMC9747889 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Emerging pharmacological treatment options for MAFLD.

Rojas Ángela Á Lara-Romero Carmen C Muñoz-Hernández Rocío R Gato Sheila S Ampuero Javier J Romero-Gómez Manuel M

Therapeutic advances in endocrinology and metabolism 20221210

Metabolic dysfunction-associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated with metabolic comorbidities, obesity, overweight, type 2 diabetes mellitus, and at least two metabolic risk factors, such as hypertension, hypertriglyceridemia, hypercholesterolemia, insulin resistance, and cardiovascular risk, increasing the risk of mortality. The excessive accumulation of fat comprises apoptosis, necrosis, inflammation and ballooning degeneration progress ...[more]

PMID: 36533188

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