Dataset Information

External validation of the risk prediction model for early diabetic kidney disease in Taiwan population: a retrospective cohort study.

ABSTRACT:

Objectives

This study aims to independently and externally validate the Risk Prediction Model for Diabetic Kidney Disease (RPM-DKD) in patients with type 2 diabetes mellitus (T2DM).

Design

This is a retrospective cohort study.

Setting

Outpatient clinics at Lee's United Clinics, Taiwan, China.

Participants

A total of 2504 patients (average age 55.44 years, SD, 7.49 years) and 4455 patients (average age 57.88 years, SD, 8.80 years) were included for analysis in the DKD prediction and progression prediction cohorts, respectively.

Exposure

The predicted risk for DKD and DKD progression for each patient were all calculated using the RPM-DKD.

Primary and secondary outcome measures

The primary outcome measure was overall incidence of DKD. Secondary outcomes included DKD progression. The discrimination, calibration and precision of the RPM-DKD score were assessed.

Results

The DKD prediction cohort and progression prediction cohort consisted of patients with 2504 and 4455 T2DM, respectively. The RPM-DKD examined in this study showed moderately discriminative ability with area under the curve ranged from 0.636 to 0.681 for the occurrence of DKD and 0.620 to 0.654 for the progression of DKD. The Hosmer-Lemeshow χ² test indicted the RPM-DKD was not well calibrated for predicting the occurrence of DKD and overestimated the progression of DKD. The precision for predicting the occurrence and progression of DKD were 43.2% and 42.2%, respectively.

Conclusions

On external validation, the RPM-DKD cannot accurately predict the risk of DKD occurrence and progression in patients with T2DM.

SUBMITTER: Sun Z

PROVIDER: S-EPMC9748925 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

External validation of the risk prediction model for early diabetic kidney disease in Taiwan population: a retrospective cohort study.

Sun Zhenzhen Z Wang Kun K Miller Joshua D JD Yuan Xiaodan X Lee Yau-Jiunn YJ Lou Qingqing Q

BMJ open 20221213 12

<h4>Objectives</h4>This study aims to independently and externally validate the Risk Prediction Model for Diabetic Kidney Disease (RPM-DKD) in patients with type 2 diabetes mellitus (T2DM).<h4>Design</h4>This is a retrospective cohort study.<h4>Setting</h4>Outpatient clinics at Lee's United Clinics, Taiwan, China.<h4>Participants</h4>A total of 2504 patients (average age 55.44 years, SD, 7.49 years) and 4455 patients (average age 57.88 years, SD, 8.80 years) were included for analysis in the DKD ...[more]

PMID: 36523225

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Dataset Information

External validation of the risk prediction model for early diabetic kidney disease in Taiwan population: a retrospective cohort study.

Objectives

Design

Setting

Participants

Exposure

Primary and secondary outcome measures

Results

Conclusions

Publications

External validation of the risk prediction model for early diabetic kidney disease in Taiwan population: a retrospective cohort study.

Similar Datasets

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