Dataset Information

Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials.

ABSTRACT:

Objective

To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome and non-COVID-19-associated acute respiratory distress syndrome.

Methods

We combined data from two randomized trials in acute respiratory distress syndrome, one including only COVID-19 patients and the other including only patients without COVID-19, to determine whether COVID-19-associated acute respiratory distress syndrome is associated with higher 28-day mortality than non-COVID-19 acute respiratory distress syndrome and to examine the differences in lung mechanics between these two types of acute respiratory distress syndrome.

Results

A total of 299 patients with COVID-19-associated acute respiratory distress syndrome and 1,010 patients with non-COVID-19-associated acute respiratory distress syndrome were included in the main analysis. The results showed that non-COVID-19 patients used higher positive end-expiratory pressure (12.5cmH2O; SD 3.2 versus 11.7cmH2O SD 2.8; p < 0.001), were ventilated with lower tidal volumes (5.8mL/kg; SD 1.0 versus 6.5mL/kg; SD 1.2; p < 0.001) and had lower static respiratory compliance adjusted for ideal body weight (0.5mL/cmH2O/kg; SD 0.3 versus 0.6mL/cmH2O/kg; SD 0.3; p = 0.01). There was no difference between groups in 28-day mortality (52.3% versus 58.9%; p = 0.52) or mechanical ventilation duration in the first 28 days among survivors (13 [IQR 5 - 22] versus 12 [IQR 6 - 26], p = 0.46).

Conclusion

This analysis showed that patients with non-COVID-19-associated acute respiratory distress syndrome have different lung mechanics but similar outcomes to COVID-19-associated acute respiratory distress syndrome patients. After propensity score matching, there was no difference in lung mechanics or outcomes between groups.

SUBMITTER: Tomazini BM

PROVIDER: S-EPMC9749099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials.

Tomazini Bruno Martins BM Costa Eduardo Leite Vieira ELV Besen Bruno Adler Maccagnan Pinheiro BAMP Zampieri Fernando Godinho FG Carvalho Carlos Roberto Ribeiro de CRR Caser Eliana Bernardete EB Souza-Dantas Vicente Cés de VC Boschi Emerson E Fumis Renata Rego Lins RRL Alencar Filho Meton Soares de MS Maia Israel Silva IS Oliveira Filho Wilson de W Veiga Viviane Cordeiro VC Avezum Alvaro A Lopes Renato Delascio RD Machado Flávia Ribeiro FR Berwanger Otávio O Rosa Regis Goulart RG Cavalcanti Alexandre Biasi AB Azevedo Luciano César Pontes de LCP

Revista Brasileira de terapia intensiva 20221104 3

<h4>Objective</h4>To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome and non-COVID-19-associated acute respiratory distress syndrome.<h4>Methods</h4>We combined data from two randomized trials in acute respiratory distress syndrome, one including only COVID-19 patients and the other including only patients without COVID-19, to determine whether COVID-19-associated acute respiratory distress syndrome is associated with higher 28-day mortalit ...[more]

PMID: 36351065

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Dataset Information

Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials.

Objective

Methods

Results

Conclusion

Publications

Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials.

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