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Reactivation of occult hepatitis B virus infection in a renal transplant recipient.

ABSTRACT: We report a case of hepatitis B virus (HBV) reactivation in a renal transplant recipient. Reactivation manifested as an occult infection with detectable HBV-DNA and negativity for hepatitis B surface antigen (HBsAg). The anti-HBs antibody titre was above the protective threshold and continued to rise, to 951.36 mIU/ml, after HBV reactivation. Sequencing revealed multiple vaccine- and diagnostic-escape mutations in the major hydrophilic region of HBsAg. This case demonstrates both reactivation of an HBV escape mutant in a vaccinated patient and host immunity after virus mutation.

SUBMITTER: Jiang L

PROVIDER: S-EPMC9753329 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Reactivation of occult hepatitis B virus infection in a renal transplant recipient.

Jiang Lili L Wang Huiqi H Huang Yaping Y Liang Hanying H Wang Xiaodong X Fan Jun J

Virology journal 20221215 1

We report a case of hepatitis B virus (HBV) reactivation in a renal transplant recipient. Reactivation manifested as an occult infection with detectable HBV-DNA and negativity for hepatitis B surface antigen (HBsAg). The anti-HBs antibody titre was above the protective threshold and continued to rise, to 951.36 mIU/ml, after HBV reactivation. Sequencing revealed multiple vaccine- and diagnostic-escape mutations in the major hydrophilic region of HBsAg. This case demonstrates both reactivation of ...[more]

PMID: 36522738

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection.

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Occult hepatitis B virus infection among blood donors in Colombia.

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| S-EPMC4256746 | biostudies-literature

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