Extracellular Matrix Microparticles Improve GelMA Bioink Resolution for 3D Bioprinting at Ambient Temperature.
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ABSTRACT: Introduction
Current bioinks for 3D bioprinting, such as gelatin-methacryloyl, are generally low viscosity fluids at room temperature, requiring specialized systems to create complex geometries.Methods and results
Adding decellularized extracellular matrix microparticles derived from porcine tracheal cartilage to gelatin-methacryloyl creates a yield stress fluid capable of forming self-supporting structures. This bioink blend performs similarly at 25°C to gelatin-methacryloyl alone at 15°C in linear resolution, print fidelity, and tensile mechanics.Conclusion
This method lowers barriers to manufacturing complex tissue geometries and removes the need for cooling systems.
SUBMITTER: Galliger Z
PROVIDER: S-EPMC9757590 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Extracellular Matrix Microparticles Improve GelMA Bioink Resolution for 3D Bioprinting at Ambient Temperature.
Galliger Zachary Z Vogt Caleb D CD Helms Haylie R HR Panoskaltsis-Mortari Angela A
Macromolecular materials and engineering 20220721 10
<h4>Introduction</h4>Current bioinks for 3D bioprinting, such as gelatin-methacryloyl, are generally low viscosity fluids at room temperature, requiring specialized systems to create complex geometries.<h4>Methods and results</h4>Adding decellularized extracellular matrix microparticles derived from porcine tracheal cartilage to gelatin-methacryloyl creates a yield stress fluid capable of forming self-supporting structures. This bioink blend performs similarly at 25°C to gelatin-methacryloyl alo ...[more]
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