Safety and immunogenicity of a novel hexavalent group B streptococcus conjugate vaccine in healthy, non-pregnant adults: a phase 1/2, randomised, placebo-controlled, observer-blinded, dose-escalation trial.
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ABSTRACT:
SUBMITTER: Absalon J
PROVIDER: S-EPMC9760110 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Safety and immunogenicity of a novel hexavalent group B streptococcus conjugate vaccine in healthy, non-pregnant adults: a phase 1/2, randomised, placebo-controlled, observer-blinded, dose-escalation trial.
Absalon Judith J Segall Nathan N Block Stan L SL Center Kimberly J KJ Scully Ingrid L IL Giardina Peter C PC Peterson James J Watson Wendy J WJ Gruber William C WC Jansen Kathrin U KU Peng Yahong Y Munson Samantha S Pavliakova Danka D Scott Daniel A DA Anderson Annaliesa S AS
The Lancet. Infectious diseases 20200903 2
<h4>Background</h4>Group B streptococcus (GBS) is a major cause of invasive disease in young infants. Infants born to women with sufficient pre-existing anti-GBS capsular IgG antibodies are at reduced risk of GBS disease, making maternal immunisation a potential strategy for prevention. We aimed to assess the safety and immunogenicity of a novel hexavalent (serotypes Ia, Ib, II, III, IV, and V) GBS conjugate vaccine (GBS6).<h4>Methods</h4>This phase 1/2, placebo-controlled, observer-blinded, dos ...[more]
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