Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels.
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ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC9764022 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels.
Lee Sun-Joo SJ Nichols Colin G CG
The Journal of general physiology 20221216 2
Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085) provide unprecedented visualization of K+ conduction through open Kir2.2 channels and of the molecular details of channel block by spermine. ...[more]
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