Ontology highlight
ABSTRACT:
SUBMITTER: Morgillo CM
PROVIDER: S-EPMC9779292 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Morgillo Carmine Marco CM Lupia Antonio A Deplano Alessandro A Pirone Luciano L Fiorillo Bianca B Pedone Emilia E Luque F Javier FJ Onnis Valentina V Moraca Federica F Catalanotti Bruno B
International journal of molecular sciences 20221207 24
Fatty acid amide hydrolase (FAAH) plays a key role in the control of cannabinoid signaling and it represents a promising therapeutic strategy for the treatment of a wide range of diseases, including neuropathic pain and chronic inflammation. Starting from kinetics experiments carried out in our previous work for the most potent inhibitor 2-amino-3-chloropyridine amide (TPA14), we have investigated its non-competitive mechanism of action using molecular dynamics, thermodynamic integration and QM- ...[more]