DNA rearrangements in the flagellin locus of an flaA mutant of Campylobacter jejuni during colonization of chicken ceca.
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ABSTRACT:
SUBMITTER: Nuijten PJ
PROVIDER: S-EPMC97826 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
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DNA rearrangements in the flagellin locus of an flaA mutant of Campylobacter jejuni during colonization of chicken ceca.
Nuijten P J PJ van den Berg A J AJ Formentini I I van der Zeijst B A BA Jacobs A A AA
Infection and immunity 20001201 12
Campylobacter jejuni is an enteropathogen for humans but commensal for chickens. In both hosts, the flagella and motility are important colonization factors. The flagellin gene is duplicated in Campylobacter, but only one flagellin gene, flaA, is sufficient for motility. We found that, during colonization of the chicken intestine, a nonmotile flaA mutant of C. jejuni underwent rearrangements within its flagellin locus, thereby regaining its motility and colonization capacity. In contrast, in vit ...[more]
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