TREM2 dependent and independent functions of microglia in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Hou J
PROVIDER: S-EPMC9783481 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
TREM2 dependent and independent functions of microglia in Alzheimer's disease.
Hou Jinchao J Chen Yun Y Grajales-Reyes Gary G Colonna Marco M
Molecular neurodegeneration 20221223 1
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia respon ...[more]
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