Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC9784159 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Song Xiaowei X Cao Wenyan W Wang Zexu Z Li Feng F Xiao Ji J Zeng Qiongzhen Q Wang Yuan Y Li Shan S Ye Cuifang C Wang Yifei Y Zheng Kai K
International journal of molecular sciences 20221216 24
HSV-1 is a typical neurotropic virus that infects the brain and causes keratitis, cold sores, and occasionally, acute herpes simplex encephalitis (HSE). The large amount of proinflammatory cytokines induced by HSV-1 infection is an important cause of neurotoxicity in the central nervous system (CNS). Microglia, as resident macrophages in CNS, are the first line of defense against neurotropic virus infection. Inhibiting the excessive production of inflammatory cytokines in overactivated microglia ...[more]