Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3).
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ABSTRACT:
SUBMITTER: Devinney R
PROVIDER: S-EPMC97919 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Publications
Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3).
Devinney R R Nisan I I Ruschkowski S S Rosenshine I I Finlay B B BB
Infection and immunity 20010101 1
Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins. ...[more]
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