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Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum.


ABSTRACT: A series of novel macrolides were discovered from the culture supernatant of the rare soil actinobacteria Dactylosporangium fulvum and named dactylosporolides A-C. The structure and absolute configuration of these dactylosporolides were defined using a combination of NMR structural elucidation and analysis of the dactylosporolide biosynthetic gene cluster. Together these data revealed dactylosporolides to be composed of a central 22-membered macrolactone with an internal hemiketal ring and a protruding ketide tail that were (poly)glycosylated at two distal parts. While bearing no antibiotic activity, these dactylosporolides displayed activity against Plasmodium falciparum 3D7.

SUBMITTER: Caradec T 

PROVIDER: S-EPMC9791991 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Dactylosporolides: Glycosylated Macrolides from <i>Dactylosporangium fulvum</i>.

Caradec Thibault T   Trivelli Xavier X   Desmecht Eva E   Peucelle Veronique V   Khalife Jamal J   Hartkoorn Ruben C RC  

Journal of natural products 20221213 12


A series of novel macrolides were discovered from the culture supernatant of the rare soil actinobacteria <i>Dactylosporangium fulvum</i> and named dactylosporolides A-C. The structure and absolute configuration of these dactylosporolides were defined using a combination of NMR structural elucidation and analysis of the dactylosporolide biosynthetic gene cluster. Together these data revealed dactylosporolides to be composed of a central 22-membered macrolactone with an internal hemiketal ring an  ...[more]

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