Ontology highlight
ABSTRACT:
SUBMITTER: Brookes E
PROVIDER: S-EPMC9792897 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Brookes Emily E Martinez De La Cruz Braulio B Boulasiki Paraskevi P Au Ho Yu Alan HYA Varsally Wazeer W Barrington Christopher C Hadjur Suzana S Riccio Antonella A
iScience 20221201 1
Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the <i>Bdnf</i> gene, which promotes the expression of <i>Bdnf</i> transcript variants during mouse neuronal differentiation and activity. Following <i>Bdnf</i> activation, enhancer-promoter contacts increase, and the region moves away from the repressive nuclear periphery. ...[more]