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baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome.


ABSTRACT: BAZ1B is a ubiquitously expressed nuclear protein with roles in chromatin remodeling, DNA replication and repair, and transcription. Reduced BAZ1B expression disrupts neuronal and neural crest development. Variation in the activity of BAZ1B has been proposed to underly morphological and behavioral aspects of domestication through disruption of neural crest development. Knockdown of baz1b in Xenopus embryos and Baz1b loss-of-function (LoF) in mice leads to craniofacial defects consistent with this hypothesis. We generated baz1b LoF zebrafish using CRISPR/Cas9 gene editing to test the hypothesis that baz1b regulates behavioral phenotypes associated with domestication in addition to craniofacial features. Zebrafish with baz1b LoF show mild underdevelopment at larval stages and distinctive craniofacial features later in life. Mutant zebrafish show reduced anxiety-associated phenotypes and an altered ontogeny of social behaviors. Thus, in zebrafish, developmental deficits in baz1b recapitulate both morphological and behavioral phenotypes associated with the domestication syndrome in other species.

SUBMITTER: Torres-Perez JV 

PROVIDER: S-EPMC9793288 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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<i>baz1b</i> loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome.

Torres-Pérez Jose V JV   Anagianni Sofia S   Mech Aleksandra M AM   Havelange William W   García-González Judit J   Fraser Scott E SE   Vallortigara Giorgio G   Brennan Caroline H CH  

iScience 20221201 1


BAZ1B is a ubiquitously expressed nuclear protein with roles in chromatin remodeling, DNA replication and repair, and transcription. Reduced <i>BAZ1B</i> expression disrupts neuronal and neural crest development. Variation in the activity of BAZ1B has been proposed to underly morphological and behavioral aspects of domestication through disruption of neural crest development. Knockdown of <i>baz1b</i> in <i>Xenopus</i> embryos and <i>Baz1b</i> loss-of-function (LoF) in mice leads to craniofacial  ...[more]

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