Ontology highlight
ABSTRACT:
SUBMITTER: Hossain KFB
PROVIDER: S-EPMC9794728 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Hossain Kaniz Fatima Binte KFB Murari Anjaneyulu A Mishra Bibhuti B Owusu-Ansah Edward E
Scientific reports 20221227 1
The boot-shaped respiratory complex I (CI) consists of a mitochondrial matrix and membrane domain organized into N-, Q- and P-modules. The N-module is the most distal part of the matrix domain, whereas the Q-module is situated between the N-module and the membrane domain. The proton-pumping P-module is situated in the membrane domain. We explored the effect of aging on the disintegration of CI and its constituent subcomplexes and modules in Drosophila flight muscles. We find that the fully-assem ...[more]