Ontology highlight
ABSTRACT:
SUBMITTER: Llibre A
PROVIDER: S-EPMC9795069 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Llibre Alba A Smith Nikaïa N Rouilly Vincent V Musvosvi Munyaradzi M Nemes Elisa E Posseme Céline C Mabwe Simbarashe S Charbit Bruno B Mbandi Stanley Kimbung SK Filander Elizabeth E Africa Hadn H Saint-André Violaine V Bondet Vincent V Bost Pierre P Mulenga Humphrey H Bilek Nicole N Albert Matthew L ML Scriba Thomas J TJ Duffy Darragh D
Frontiers in immunology 20221214
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how <i>Mycobacterium tuberculosis</i> (<i>M. tb</i>) infection impacts host immune responses. We compared the induced immune response to TB antigen, BCG and IL-1β stimulation between latently <i>M. tb</i> infected individuals (LTBI) and active TB patients. This revealed distinct responses between TB/LTBI at transcriptomic, proteomic and metabolomic levels. At baseline, we identified a novel immun ...[more]