P21 induces a senescence program and skeletal muscle dysfunction.
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ABSTRACT:
SUBMITTER: Englund DA
PROVIDER: S-EPMC9800630 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
p21 induces a senescence program and skeletal muscle dysfunction.
Englund Davis A DA Jolliffe Alyssa A Aversa Zaira Z Zhang Xu X Sturmlechner Ines I Sakamoto Ayumi E AE Zeidler Julianna D JD Warner Gina M GM McNinch Colton C White Thomas A TA Chini Eduardo N EN Baker Darren J DJ van Deursen Jan M JM LeBrasseur Nathan K NK
Molecular metabolism 20221209
Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes to cellular senescence and pathological features in skeletal muscle. We show that p21 induces several core properties of cellular senescence in skeletal muscle, including an altered transcriptome, DNA damage, mitochondrial dysfunction, and the senesc ...[more]
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