Ontology highlight
ABSTRACT:
SUBMITTER: Eisenhauer PB
PROVIDER: S-EPMC98098 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Eisenhauer P B PB Chaturvedi P P Fine R E RE Ritchie A J AJ Pober J S JS Cleary T G TG Newburg D S DS
Infection and immunity 20010301 3
Hemolytic uremic syndrome (HUS) is associated with intestinal infection by enterohemorrhagic Escherichia coli strains that produce Shiga toxins. Globotriaosylceramide (Gb3) is the functional receptor for Shiga toxin, and tumor necrosis factor alpha (TNF-alpha) upregulates Gb3 in both human macrovascular umbilical vein endothelial cells and human microvascular brain endothelial cells. TNF-alpha treatment enhanced Shiga toxin binding and sensitivity to toxin. This upregulation was specific for Gb3 ...[more]